The approved therapy Uplizna (inebilizumab) may reduce the risk of disease flares in adults with IgG4-related disease (IgG4-RD) who have kidney involvement, according to a new analysis of clinical trial data. The new analysis focuses on a subgroup of patients in the Phase 3 MITIGATE clinical trial…
News
Certain immune cell markers appear to closely track disease activity in people with IgG4-related disease (IgG4-RD), a study by researchers in South Korea suggests. The researchers identified a group of plasma cells, a type of antibody-producing B-cell, with increased activity of a gene called NMU and frequent use of…
Obexelimab, an investigational therapy for people with immunoglobulin G4-related disease (IgG4-RD), was found to reduce disease activity among participants in an IgG4-RD clinical study without eliminating the benefits of vaccination against flu and COVID-19, according to new data. Additional results from other analyses showed obexelimab can lessen the need…
The use of ultrasound imaging may help clinicians to tell the difference between a bile duct manifestation of IgG4-related disease (IgG4-RD) and cholangiocarcinoma (CCA), a type of bile duct cancer, a small study suggests. The researchers found that the noninvasive imaging test can distinguish cancer involving the bile ducts…
Lower relative levels of antibodies commonly found in immunoglobulin G4-related disease (IgG4-RD) and the absence of symptoms affecting the eyes and tear glands may help predict better response to off-label treatment with rituximab, according to a study in the U.S. Data also showed that while IgG4-RD appears to affect…
When starting treatment for IgG4-related disease (IgG4-RD), having measurements of certain immune cell levels may help doctors predict the risk of future disease flares in those with the rare condition, a new study from Japan suggests. The researchers found that high blood levels of two types of immune cells…
Immunoglobulin G4-related disease (IgG4-RD) that’s marked by swelling and tumor-like masses in the head and neck can closely mimic cancer and other inflammatory conditions, making diagnosis challenging, according to a large case series study in India. In the 18-patient study, the disease affected a broad range of head and…
In a proof-of-concept study, a team of scientists in Spain has identified a range of blood markers related to immune responses that may help to track disease activity in people with IgG4-related disease (IgG4-RD). “In this prospective longitudinal study of [untreated] patients with IgG4-RD, [statistical] models identified exploratory associations…
Elevated blood levels of an antibody called IgG1, measured alongside a specific ratio to IgG4, can help identify a more severe form of IgG4-related disease (IgG4-RD) marked by widespread organ damage, a new study shows. Because the severity of IgG4-RD varies widely from person to person, researchers say evaluating…
People with IgG4-related disease (IgG4-RD) who have very high levels of the antibody immunoglobulin G4 (IgG4) are more likely to have multi-organ involvement, a study showed. The findings suggest that extremely high antibody levels — at or above five times the upper limit of normal (ULN) — might be…
