Most adults ages 50 and older with immunoglobulin G4-related disease (IgG4-RD) have multiple organ involvement, whereas the disease predominantly affects a single organ in patients ages 25 years or younger, according to a study in Argentina. Data also showed that older patients had more pronounced involvement of lymph…
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Most people with IgG4-related cholangitis, a form of IgG4-related disease (IgG4-RD) that affects the bile ducts — the tubes that carry the digestive fluid from the liver — responded well to standard glucocorticoid therapy and had favorable long-term survival, according to a study in China. The data also…
IgG4-related sclerosing mesenteritis (IgG4-SM), a rare and often overlooked manifestation of IgG4-related disease (IgG4-RD) treated in many cases by surgery, may respond to less invasive approaches, a study from China found. IgG4-SM is marked by inflammation and scarring of the mesentery, the tissue that anchors the intestines to the…
IgG4-related disease (IgG4-RD) may affect the nervous system more often than has been previously recognized, according to a study from Turkey. Researchers found that more than one in five patients treated at their clinic had neurological involvement, most commonly manifesting as vision problems. “Although neurological manifestations of IgG4-RD are…
People with IgG4-related disease (IgG4-RD) who have a history of allergies are more likely to relapse after initial treatment, according to a recent study. Data also suggest that demographic variables and patterns of disease involvement differ between IgG4-RD patients with or without allergies. Specifically, individuals with a history of…
IgG4-related ophthalmic disease (IgG4-ROD) — IgG4-related disease (IgG4-RD) that affects the eyes — is typically treated with steroids, but some patients may need add-on immunosuppressants if the disease returns, a study found. Relapse appeared to be more common in people with high IgG4 levels in the blood or…
Obexelimab, Zenas Biopharma’s experimental, self-administered injectable therapy, reduced the risk of disease flares in adults with immunoglobulin G4-related disease (IgG4-RD), according to new Phase 3 trial results. The findings come from top-line results presented by the company from the global Phase 3 INDIGO clinical trial (NCT05662241), which…
The risk of developing cancer is more than four times higher in people with immunoglobulin G4-related disease (IgG4-RD) compared with the general population, with the greatest risk seen during the first year after diagnosis. That’s according to a large-scale nationwide study from South Korea. The researchers also found that…
People with IgG4-related disease (IgG4-RD) can experience damage to nerves and muscles, either as a result of IgG4-RD itself or due to co-occurring conditions, resulting in a wide range of symptoms, a review study showed. “A comprehensive evaluation to exclude other autoimmune diseases is crucial, including systemic vasculitis…
Researchers in Japan studying genetic data from hundreds of patients confirmed several genetic variations and identified new ones as genetic risk factors of IgG4-related disease (IgG4-RD). Two variations were associated with an increased susceptibility to IgG4-related dacryoadenitis and sialadenitis (Mikulicz’s disease), a form of IgG4-RD marked by inflammation of…
