Zenas Biopharma has submitted an application to the U.S. Food and Drug Administration (FDA) seeking approval of its experimental injection therapy, obexelimab, for immunoglobulin G4-related disease (IgG4-RD). “Our obexelimab [biologics license application] submission brings us one step closer to our goal of delivering this…
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A new imaging technique shows promise for assessing disease activity and organ involvement in immunoglobulin G4-related disease (IgG4-RD). Compared with biopsy results, the [18F]FAPI PET/CT scan was 100% accurate in detecting lesions in various organs, including the lung, liver, muscles, pancreas, and kidney. The researchers developed a disease activity…
Zenas Biopharma says it’s on track to submit applications this year in the U.S. and the European Union seeking approval of its experimental injection therapy obexelimab for treating immunoglobulin G4-related disease (IgG4-RD). In fact, the developer noted that it intends to file a biologics license application to the…
Rituximab appears to control immunoglobulin G4-related disease (IgG4-RD) about as well as glucocorticoids but allows patients to use lower doses of this type of corticosteroid — a class of steroid hormones — overall, which may prevent serious side effects, according to a large real-world study in Europe. “Our…
In rare cases where IgG4-related disease (IgG4-RD) affects the pericardium, surgery to remove all or part of this sac surrounding the heart is usually necessary to control the disease, according to a study of 5 patients in the U.S. “Medical therapy alone is often inadequate, and [surgery] remains the…
People with immunoglobulin-G4-related disease (IgG4-RD) often attend dozens of outpatient doctors’ visits in the months immediately before and after diagnosis, and many are hospitalized for more than a week at a time. That’s according to a study based on U.S. commercial insurance records that also showed healthcare-related costs increase…
Four blood proteins may help diagnose immunoglobulin G4-related disease (IgG4-RD), monitor disease activity and treatment response, and predict relapse risk, a study reveals. The four proteins also showed strong associations with standard markers of inflammation and could distinguish the disease from conditions with similar signs, including cancer. “These insights…
Researchers in Japan have described the clinical and tissue features of localized-type IgG4-related cholecystitis, a rare form of IgG4-related disease (IgG4-RD) that affects the gallbladder, which may help distinguish it from gallbladder cancer. “Understanding these … features would contribute to a more accurate differential diagnosis from [gallbladder] cancer,” the…
IgG4-related prostatitis — an inflammation of the prostate caused by IgG4-related disease (IgG4-RD) — can be easily mistaken for an enlarged prostate or prostate cancer, making diagnosis challenging, according to a systematic review of published cases to date. Still, data suggested that most men with IgG4-related prostatitis respond well…
Interactions between two specific subsets of immune cells may contribute to disease activity in people with immunoglobulin G4-related disease (IgG4-RD), according to a new study. Researchers speculated that this newly identified immune-related axis could be a potential target for new IgG4-RD treatments. The study, “Extrafollicular [Tph2–CD11c-positive,…
