Long-term treatment with rituximab — a cancer drug used despite not having specific approval — is safe and generally effective for controlling IgG4-related disease (IgG4-RD), though researchers say more study is needed to standardize its use. Those are the outcomes of a small study by scientists in Germany, who…
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Most adults ages 50 and older with immunoglobulin G4-related disease (IgG4-RD) have multiple organ involvement, whereas the disease predominantly affects a single organ in patients ages 25 years or younger, according to a study in Argentina. Data also showed that older patients had more pronounced involvement of lymph…
Most people with IgG4-related cholangitis, a form of IgG4-related disease (IgG4-RD) that affects the bile ducts — the tubes that carry the digestive fluid from the liver — responded well to standard glucocorticoid therapy and had favorable long-term survival, according to a study in China. The data also…
IgG4-related sclerosing mesenteritis (IgG4-SM), a rare and often overlooked manifestation of IgG4-related disease (IgG4-RD) treated in many cases by surgery, may respond to less invasive approaches, a study from China found. IgG4-SM is marked by inflammation and scarring of the mesentery, the tissue that anchors the intestines to the…
IgG4-related disease (IgG4-RD) may affect the nervous system more often than has been previously recognized, according to a study from Turkey. Researchers found that more than one in five patients treated at their clinic had neurological involvement, most commonly manifesting as vision problems. “Although neurological manifestations of IgG4-RD are…
People with IgG4-related disease (IgG4-RD) who have a history of allergies are more likely to relapse after initial treatment, according to a recent study. Data also suggest that demographic variables and patterns of disease involvement differ between IgG4-RD patients with or without allergies. Specifically, individuals with a history of…
IgG4-related ophthalmic disease (IgG4-ROD) — IgG4-related disease (IgG4-RD) that affects the eyes — is typically treated with steroids, but some patients may need add-on immunosuppressants if the disease returns, a study found. Relapse appeared to be more common in people with high IgG4 levels in the blood or…
Obexelimab, Zenas Biopharma’s experimental, self-administered injectable therapy, reduced the risk of disease flares in adults with immunoglobulin G4-related disease (IgG4-RD), according to new Phase 3 trial results. The findings come from top-line results presented by the company from the global Phase 3 INDIGO clinical trial (NCT05662241), which…
The risk of developing cancer is more than four times higher in people with immunoglobulin G4-related disease (IgG4-RD) compared with the general population, with the greatest risk seen during the first year after diagnosis. That’s according to a large-scale nationwide study from South Korea. The researchers also found that…
People with IgG4-related disease (IgG4-RD) can experience damage to nerves and muscles, either as a result of IgG4-RD itself or due to co-occurring conditions, resulting in a wide range of symptoms, a review study showed. “A comprehensive evaluation to exclude other autoimmune diseases is crucial, including systemic vasculitis…
