IgG4-related disease (IgG4-RD) may affect the nervous system more often than has been previously recognized, according to a study from Turkey. Researchers found that more than one in five patients treated at their clinic had neurological involvement, most commonly manifesting as vision problems. “Although neurological manifestations of IgG4-RD are…
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People with IgG4-related disease (IgG4-RD) who have a history of allergies are more likely to relapse after initial treatment, according to a recent study. Data also suggest that demographic variables and patterns of disease involvement differ between IgG4-RD patients with or without allergies. Specifically, individuals with a history of…
IgG4-related ophthalmic disease (IgG4-ROD) — IgG4-related disease (IgG4-RD) that affects the eyes — is typically treated with steroids, but some patients may need add-on immunosuppressants if the disease returns, a study found. Relapse appeared to be more common in people with high IgG4 levels in the blood or…
Obexelimab, Zenas Biopharma’s experimental, self-administered injectable therapy, reduced the risk of disease flares in adults with immunoglobulin G4-related disease (IgG4-RD), according to new Phase 3 trial results. The findings come from top-line results presented by the company from the global Phase 3 INDIGO clinical trial (NCT05662241), which…
The risk of developing cancer is more than four times higher in people with immunoglobulin G4-related disease (IgG4-RD) compared with the general population, with the greatest risk seen during the first year after diagnosis. That’s according to a large-scale nationwide study from South Korea. The researchers also found that…
People with IgG4-related disease (IgG4-RD) can experience damage to nerves and muscles, either as a result of IgG4-RD itself or due to co-occurring conditions, resulting in a wide range of symptoms, a review study showed. “A comprehensive evaluation to exclude other autoimmune diseases is crucial, including systemic vasculitis…
Researchers in Japan studying genetic data from hundreds of patients confirmed several genetic variations and identified new ones as genetic risk factors of IgG4-related disease (IgG4-RD). Two variations were associated with an increased susceptibility to IgG4-related dacryoadenitis and sialadenitis (Mikulicz’s disease), a form of IgG4-RD marked by inflammation of…
Researchers in Japan have described the clinical features of a large group of people with IgG4-related disease (IgG4-RD) affecting the gastrointestinal tract, shedding new light on this poorly characterized manifestation of the condition. In addition to four previously reported hallmark tissue features, IgG4-related gastrointestinal disease (IgG4-GID) appeared almost exclusively…
Nearly one in 10 people with immunoglobulin G4-related disease (IgG4-RD) also have at least one co-existing autoimmune disease, according to a real-world study in China. Researchers identified 19 different autoimmune diseases in 85 IgG4-RD patients, most of which developed before or concurrently with the IgG4-RD diagnosis. Even so,…
Measuring a specific type of antibody in the blood called immunoglobulin G4 (IgG4) is proving to be a highly effective tool for doctors to diagnose, assess, and monitor the rare and complex condition known as IgG4-related disease (IgG4-RD). A study found that elevated IgG4 levels correlate strongly with multi-organ…
