A specific subset of immune cells known as gamma-delta 2 T-cells plays a key role in the development of immunoglobulin G4-related disease (IgG4-RD), a study reports. Particularly, these cells were found to acquire an immune profile, called T helper 2 (Th2)-like phenotype, to strongly promote the formation of plasma…
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More than 50,000 people in the U.S. were living with IgG4-related disease (IgG4-RD) as of 2024, a new report on statistics related to the rare immune disease shows. The report provides IgG4-RD epidemiology data, such as the disease’s occurrence, distribution, and patterns, in the U.S. as well as in…
People with immunoglobulin G4-related disease (IgG4-RD) may be susceptible to developing multiple cancers and should be carefully monitored, according to a new report from researchers in Turkey. In reviewing previously published reports, the scientists found that people who experienced multiple cancers, or malignancies, tended to be older than those…
Sinonasal involvement, with symptoms affecting the nasal passages and surrounding air-filled skull cavities (sinuses), may be an under-recognized presentation of immunoglobulin G4-related disease (IgG4-RD), according to a review study. Nasal and eye-related symptoms were common in patients with sinonasal involvement, though many cases also involved other organ systems considered more…
Lung abnormalities associated with immunoglobulin G4-related disease (IgG4-RD) can show up in a number of ways on a chest CT scan and certain abnormalities increase the likelihood of lung problems as first symptoms, a study shows. These findings emphasize the importance of performing a chest CT when a person…
About two-thirds of people with a definitive immunoglobulin G4-related disease (IgG4-RD) diagnosis and eye involvement also have signs of the condition in other parts of the body, according to a study involving patients from more than 20 hospitals in the Republic of Korea. The researchers say their findings highlight…
A greater use of glucocorticoids — a class of steroid medications — was associated with more toxicities, such as cardiovascular, gastrointestinal, and infection-related issues in people with immunoglobulin G4-related disease (IgG4-RD), a study finds. The side effects were particularly common where IgG4-RD affected the pancreas and bile ducts,…
