Imaging of the salivary glands can help distinguish IgG4-related disease (IgG4-RD) from other disorders that can cause inflammation in those glands, a new study shows. The findings indicate people with salivary gland inflammation related to IgG4-RD tend to show distinctive patterns of damage to some of the tubes, or…
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Type 1 autoimmune pancreatitis (AIP), a type of IgG4-related disease (IgG4-RD) involving the pancreas, can look different depending on the levels of immunoglobulin G4 (IgG4), a study found. People with normal IgG4 levels typically had more limited damage in the pancreas and some issues outside it, the researchers found.
Eye problems, inflammation in the brain’s pituitary gland, and thickening of the membranes around the brain and spinal cord are the most common neurological complications seen with immunoglobulin G4-related disease (IgG4-RD), a review study reports. Neurological problems in IgG4-RD can usually be managed with standard treatments, though researchers emphasized…
High blood levels of IgG4 antibodies may be a sign of many diseases, not solely IgG4-related disease (IgG4-RD), but blood tests for IgG4 can identify most IgG-RD cases and rule it out for most people without the disease, a study in Spain reports. Certain respiratory conditions, autoimmune diseases, and…
High levels of IgG4 antibodies are not associated with an increased risk of clinical disease activity in people with IgG4-related disease (IgG4-RD) who don’t have active IgG4-RD symptoms, but a sudden rise in these antibodies may predict the recurrence of symptoms, a study found. Monitoring for rising IgG4…
A ratio of different types of immune cells called the eosinophil-to-lymphocyte ratio (ELR) may predict risk of relapse in people with immunoglobulin G4-related disease (IgG4-RD), according to a long-term study. People with IgG4-RD had higher ELRs than those with other inflammatory diseases, and a higher ELR was associated with…
A specific subset of immune cells known as gamma-delta 2 T-cells plays a key role in the development of immunoglobulin G4-related disease (IgG4-RD), a study reports. Particularly, these cells were found to acquire an immune profile, called T helper 2 (Th2)-like phenotype, to strongly promote the formation of plasma…
More than 50,000 people in the U.S. were living with IgG4-related disease (IgG4-RD) as of 2024, a new report on statistics related to the rare immune disease shows. The report provides IgG4-RD epidemiology data, such as the disease’s occurrence, distribution, and patterns, in the U.S. as well as in…
People with immunoglobulin G4-related disease (IgG4-RD) may be susceptible to developing multiple cancers and should be carefully monitored, according to a new report from researchers in Turkey. In reviewing previously published reports, the scientists found that people who experienced multiple cancers, or malignancies, tended to be older than those…
Sinonasal involvement, with symptoms affecting the nasal passages and surrounding air-filled skull cavities (sinuses), may be an under-recognized presentation of immunoglobulin G4-related disease (IgG4-RD), according to a review study. Nasal and eye-related symptoms were common in patients with sinonasal involvement, though many cases also involved other organ systems considered more…
