Mikulicz disease — a rare pattern of organ involvement linked to IgG4-related disease (IgG4-RD) — is often misunderstood. This deeply disruptive condition is multiglandular, affecting the lacrimal glands (which produce tears), the parotid and submandibular glands (major salivary glands), and the lymphatic chain in the head and neck. When…
Discussion
People with IgG4-related disease (IgG4-RD) who have very high levels of the antibody immunoglobulin G4 (IgG4) are more likely to have multi-organ involvement, a study showed. The findings suggest that extremely high antibody levels — at or above five times the upper limit of normal (ULN) — might be…
Discussion
The U.S. Food and Drug Administration (FDA) is now slated to decide by next year whether or not to approve the novel injection therapy obexelimab for immunoglobulin G4-related disease (IgG4-RD). The regulatory agency has accepted a biologics license application (BLA) from Zenas Biopharma, the therapy’s developer,…
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